Professional Pathology Services autopsy service provides support for both the Palmetto Health campuses, as well as providing forensic pathology services for Richland County. The main objective for hospital-generated autopsies is clinical-pathological correlation. The information collected from the autopsy is discussed with the clinician and, if necessary, with family members to provide relevant details of the patient's life. Family members may contract with the autopsy service for a private autopsy on a fee per service basis.

A forensic autopsy is usually conducted for people who have died as a result of an unnatural, untimely, or suspicious death. These cases are under the jurisdiction of the Richland County Coroner who authorizes the autopsy. The information gained from the examination is intended to not only provide information for the cause of death, but also the manner of death.